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Mitral Annular Calcification In Stage 5 Chronic Kidney Disease On Dialysis Therapy
Abeera Mansur1, Sidra Saleem2, Haris Naveed3
1Doctors Hospital and Medical Center, Lahore, Pakistan.
Journal of Ayub Medical College, Abbottabad : JAMC
|June 26, 2020
Summary
Mitral annular calcification (MAC) is prevalent in 44% of hemodialysis patients and significantly correlates with ischemic heart disease (IHD). Longer dialysis duration increases MAC risk, supporting echocardiography for valvular calcification detection.
Area of Science:
- Cardiology
- Nephrology
- Valvular Heart Disease
Background:
- Mitral annular calcification (MAC) is a degenerative process and marker of cardiovascular disease.
- Prevalence increases with age, diabetes, and chronic kidney disease (CKD), reaching up to 40% in end-stage renal disease.
- CKD patients, particularly those on dialysis, represent a high-risk population for MAC.
Purpose of the Study:
- To determine the prevalence of MAC in patients with stage 5 CKD on hemodialysis.
- To identify patient characteristics associated with MAC in this population.
- To correlate MAC with cardiovascular outcomes and mortality.
Main Methods:
- Echocardiograms were performed on 84 hemodialysis patients.
- Statistical analysis was used to assess the association between MAC and patient characteristics.
- Patient data included demographics, comorbidities, dialysis duration, and laboratory values.
Main Results:
- MAC was present in 44% of the 84 hemodialysis patients.
- MAC significantly correlated with ischemic heart disease (IHD) (OR=6.42, p=0.006).
- Dialysis duration exceeding 36 months (OR=3.32, p=0.019) and IHD were significant risk factors for MAC.
Conclusions:
- Mitral annular calcification is common in hemodialysis patients.
- MAC is significantly associated with IHD in this cohort.
- Echocardiography is recommended for detecting valvular calcification in CKD patients, aligning with KDIGO guidelines.
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