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Mitral Annular Calcification In Stage 5 Chronic Kidney Disease On Dialysis Therapy

Abeera Mansur1, Sidra Saleem2, Haris Naveed3

  • 1Doctors Hospital and Medical Center, Lahore, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC
|June 26, 2020
PubMed

Insights

Mitral annular calcification (MAC) is prevalent in 44% of hemodialysis patients and significantly correlates with ischemic heart disease (IHD). Longer dialysis duration increases MAC risk, supporting echocardiography for valvular calcification detection.

Area of Science:

  • Cardiology
  • Nephrology
  • Valvular Heart Disease

Background:

  • Mitral annular calcification (MAC) is a degenerative process and marker of cardiovascular disease.
  • Prevalence increases with age, diabetes, and chronic kidney disease (CKD), reaching up to 40% in end-stage renal disease.
  • CKD patients, particularly those on dialysis, represent a high-risk population for MAC.

Purpose of the Study:

  • To determine the prevalence of MAC in patients with stage 5 CKD on hemodialysis.
  • To identify patient characteristics associated with MAC in this population.
  • To correlate MAC with cardiovascular outcomes and mortality.

Main Methods:

  • Echocardiograms were performed on 84 hemodialysis patients.
  • Statistical analysis was used to assess the association between MAC and patient characteristics.
  • Patient data included demographics, comorbidities, dialysis duration, and laboratory values.

Main Results:

  • MAC was present in 44% of the 84 hemodialysis patients.
  • MAC significantly correlated with ischemic heart disease (IHD) (OR=6.42, p=0.006).
  • Dialysis duration exceeding 36 months (OR=3.32, p=0.019) and IHD were significant risk factors for MAC.

Conclusions:

  • Mitral annular calcification is common in hemodialysis patients.
  • MAC is significantly associated with IHD in this cohort.
  • Echocardiography is recommended for detecting valvular calcification in CKD patients, aligning with KDIGO guidelines.
Abstract

Keywords:
Chronic Kidney Disease; Cardiovascular diseaseMitral Value; Annular calcification

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