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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

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What We Learned about COVID-19 So Far? Notes from Underground.

Fatma Tokgöz Akyıl¹, Dilek Karadoğan², Canan Gündüz Gürkan³

¹Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.

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|June 26, 2020

Summary

This review summarizes the latest COVID-19 research, covering epidemiology, clinical findings, and treatments. Key findings include common symptoms like fever and cough, and potential drug candidates for managing coronavirus disease 2019.

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Area of Science:

* Public Health
* Infectious Diseases
* Respiratory Medicine

Background:

* The novel coronavirus (SARS-CoV-2) pandemic presents a significant global health challenge.
* Knowledge regarding COVID-19 is rapidly evolving with increasing worldwide data.
* The virus shares genetic similarities with SARS-CoV and MERS-CoV, utilizing the ACE2 receptor for entry.

Purpose of the Study:

* To provide a narrative review of recent literature on COVID-19.
* To summarize key aspects including epidemiology, clinical presentation, diagnosis, treatment, and prevention.
* To offer insights for healthcare professionals and researchers.

Main Methods:

* Narrative review of existing scientific literature.
* Synthesis of data from global studies on COVID-19.
* Focus on early career taskforce findings and recommendations.

Main Results:

* Common symptoms include fever and cough; smokers face higher risks. Mean incubation is 6.4 days; asymptomatic transmission can last up to 25 days.
* Clinical manifestations range from mild to severe acute respiratory distress syndrome (ARDS). Typical radiological findings include bilateral ground-glass opacities.
* Poor prognosis linked to older age, high SOFA scores, and elevated D-dimer. Chloroquine, lopinavir/ritonavir, favipiravir, and remdesivir show potential therapeutic benefits.

Conclusions:

* COVID-19 presents diverse clinical and radiological features, with ACE2 receptor involvement.
* Several potential treatments are under investigation, but further research is needed.
* Ongoing research is crucial for understanding transmission, effective treatments, and prevention strategies for coronavirus disease 2019.