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[Disoprivan (Propofol) sedation during regional anesthesia. A pilot study]
K Döbler1, E Dombrowski, H Nolte
1Institut für Anaesthesiologie, Klinikum Minden, Minden/Westfalen.
Regional-Anaesthesie
|January 1, 1988
Summary
Disoprivan (propofol) provides excellent sedation during regional anesthesia. Lower doses (1-1.5 mg/kg/hr) are effective with pleasant recovery and manageable side effects.
Area of Science:
- Anesthesiology
- Pharmacology
Context:
- Regional anesthesia is frequently used for surgical procedures.
- Sedation is often required to enhance patient comfort during regional anesthesia.
Purpose:
- To investigate the efficacy and safety of disoprivan (propofol) for sedation during lumbar epidural anesthesia.
- To evaluate the effects of different disoprivan infusion rates on cardiovascular and respiratory parameters, recovery time, and patient-reported outcomes.
Summary:
- A pilot study in 15 patients undergoing lumbar epidural anesthesia assessed disoprivan sedation at 1, 1.5, or 2 mg/kg/hr.
- Sedation with disoprivan at 1 or 1.5 mg/kg/hr was found to be effective and well-tolerated, with pleasant sleep and rapid recovery (1-12 min).
- A dose-dependent incidence of upper airway obstruction, nausea, vomiting, and injection pain was observed, all manageable or transient.
Impact:
- Disoprivan, particularly at lower infusion rates, appears to be a safe and effective option for sedation during regional anesthesia.
- It may offer advantages over existing sedatives, warranting further investigation in larger trials.