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Understanding the interplay between factors that influence bone mineral density in CF
Michal Gur1,2, Ronen Bar-Yoseph1,2, Giselle Diab1,3
1Pediatric Pulmonary Institute and CF Center, Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
Pediatric Pulmonology
|June 26, 2020
Summary
Many cystic fibrosis (CF) patients experience low bone mineral density (BMD). Age and clinical scores are key predictors, highlighting the need for further research into multifactorial causes.
Area of Science:
- Bone metabolism and cystic fibrosis research
- Clinical investigation of bone health in chronic diseases
Background:
- Bone mineral density (BMD) is frequently compromised in cystic fibrosis (CF) patients.
- Multiple factors are implicated in the etiology of low BMD in CF.
- Comprehensive analysis is needed to identify key contributing parameters.
Purpose of the Study:
- To conduct a thorough analysis of factors influencing BMD in individuals with CF.
- To investigate correlations between BMD and various clinical, nutritional, and functional parameters.
Main Methods:
- A prospective single-center study involving 40 CF patients.
- Assessment of BMD, pancreatic status, lung function (FEV1), 6-minute walk test (6MWT), Shwachman-Kulczycki (SK) score, vitamin D levels, nutritional intake, hand grip strength (HGS), physical activity (smartwatches), and quality of life (SF-36).
Main Results:
- Osteopenia and osteoporosis were present in 37.5% and 27.5% of patients, respectively.
- BMD did not differ significantly between pancreatic sufficient (PS) and pancreatic insufficient (PI) groups.
- BMD strongly correlated with HGS and fat-free mass index; age and SK score were significant predictors of spine BMD.
Conclusions:
- A significant proportion of CF patients exhibit low BMD, irrespective of pancreatic status.
- Clinical score (SK) and age emerge as important, accessible predictors of reduced BMD in CF.
- Further multicenter research is essential to elucidate the multifactorial determinants of low BMD in CF.
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