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Related Experiment Video

Updated: Dec 17, 2025

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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[Allergy testing in children].

Pernille Lindsø, Kim Kristensen1

  • 1kimk@dadlnet.dk.

Ugeskrift for Laeger
|June 26, 2020
PubMed
Summary

Allergy testing in children for asthma and allergic rhinitis is often unnecessary. For suspected food allergies, especially peanuts, specific tests are recommended over general screening, and penicillin allergy can be diagnosed via provocation.

Area of Science:

  • Pediatric Allergy and Immunology
  • Clinical Diagnostics

Background:

  • Asthma and allergic rhinitis are common in children, often without identifiable triggers.
  • Atopic dermatitis frequently co-exists with other allergic conditions.
  • Current diagnostic approaches for food allergies can be overly broad and lead to unnecessary restrictions.

Purpose of the Study:

  • To evaluate the utility of routine allergy testing in pediatric asthma and allergic rhinitis.
  • To define appropriate diagnostic pathways for suspected food allergies in children.
  • To assess the role of provocation testing versus serological/skin testing for specific allergies.

Main Methods:

  • Review of existing literature and clinical guidelines on pediatric allergy diagnosis.
  • Analysis of the diagnostic yield of skin prick tests (SPT) and specific immunoglobulin E (sIgE) testing.

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  • Consideration of component-resolved diagnostics (CRD) and oral food challenges (OFC).

    • Main Results:

    • Routine allergy testing shows limited clinical utility in children with asthma and allergic rhinitis.
    • SPT and sIgE testing often yield results inconsistent with clinical reactivity.
    • Oral food challenges are the gold standard for diagnosing food allergy, except for peanut allergy where CRD may suffice.

    Conclusions:

    • Allergy testing should be judiciously applied in pediatric allergic diseases.
    • Focus should be on targeted testing when specific allergies are clinically suspected, particularly for food allergies.
    • Provocation testing is a reliable method for diagnosing penicillin allergy and some food allergies.