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Updated: Dec 17, 2025

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

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Published on: November 10, 2017

Anthocyanins decrease the internalization of TiO₂ nanoparticles into 3D Caco-2 spheroids.

Junkang Wang¹, Jiaqi Zhang¹, Shuang Li¹

¹Key Laboratory of Environment-Friendly Chemistry and Applications of Ministry Education, Laboratory of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan 411105, PR China.

|June 26, 2020

Summary

This summary is machine-generated.

Anthocyanins minimally affect titanium dioxide nanoparticle (TiO2 NP) stability but bind to them. This binding reduces NP internalization into intestinal cells, potentially via ABC transporter changes.

Keywords:

3D Caco-2 spheroids Anthocyanins Binding affinity constants Internalization TiO(2) nanoparticles (NPs)

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Area of Science:

Nanotechnology
Food Science
Toxicology

Background:

Food components influence nanoparticle (NP) behavior in complex systems.
Understanding NP-food interactions is crucial for safety assessments.

Purpose of the Study:

To investigate the impact of anthocyanins on titanium dioxide nanoparticle (TiO2 NP) colloidal stability and bio-effects.
To elucidate the interaction mechanisms between anthocyanins and TiO2 NPs in a human intestinal cell model.

Main Methods:

Assessed TiO2 NP colloidal stability and anthocyanin fluorescence quenching.
Evaluated cytotoxicity, oxidative stress, ABC transporter expression, and intracellular titanium (Ti) concentrations.
Utilized 3D Caco-2 spheroids for co-exposure studies.

Main Results:

Anthocyanins showed minimal impact on TiO2 NP colloidal properties.
NP-anthocyanin co-exposure did not induce cytotoxicity or oxidative stress.
Anthocyanin binding to TiO2 NPs was observed, inversely correlating with NP internalization.

Conclusions:

Anthocyanin binding to TiO2 NPs may reduce their internalization into intestinal cells.
Up-regulation of ABC transporters might play a role in this reduced internalization.
Findings offer insights into NP-anthocyanin interactions within the human gut.