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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
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Polyphenols as Possible Agents for Pancreatic Diseases
Uroš Gašić1, Ivanka Ćirić2, Tomislav Pejčić3
1Department of Plant Physiology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
Antioxidants (Basel, Switzerland)
|June 27, 2020
Summary
Polyphenols from fruits like apples and berries show promise in fighting pancreatic cancer (PC) and preventing pancreatitis. This review details their anticancer effects and optimal consumption for therapeutic benefits.
Area of Science:
- Oncology
- Nutraceuticals
- Biochemistry
Background:
- Pancreatic cancer (PC) is highly aggressive with poor prognosis.
- Early diagnosis of PC is challenging due to non-specific symptoms.
- Current treatments include gemcitabine and other chemotherapies, with limited efficacy.
Purpose of the Study:
- To review the therapeutic potential of polyphenols in pancreatic cancer treatment and pancreatitis prevention.
- To analyze the anticancer effects of pure polyphenols and plant extracts against PC.
- To investigate the role of fruit-derived polyphenols and anthocyanins.
Main Methods:
- Literature review of research on polyphenols and pancreatic diseases.
- Analysis of studies on antiproliferative and antimetastatic effects of polyphenols.
- Examination of polyphenol profiles in apples, berries, cherries, and grapes.
Main Results:
- Polyphenols exhibit antiproliferative and antimetastatic effects against pancreatic cancer cell lines.
- Certain plant extracts and pure polyphenols show potential in preventing acute pancreatitis.
- Specific fruits like apples, berries, cherries, and grapes are rich sources of therapeutic polyphenols.
Conclusions:
- Polyphenols represent a promising natural approach for pancreatic cancer therapy and pancreatitis prevention.
- Understanding the polyphenol content of fruits can guide dietary recommendations for therapeutic effects.
- Further research into specific fruit-derived polyphenols is warranted for clinical application.
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