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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
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Published on: July 27, 2021

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Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

Christiane Iserman1, Christine Roden1,2, Mark Boerneke3

  • 1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Biorxiv : the Preprint Server for Biology
|June 27, 2020
PubMed
Summary

The SARS-CoV-2 nucleocapsid protein (N-protein) forms liquid-like condensates with viral RNA, crucial for packaging. This process, temperature-sensitive and targetable with small molecules, offers new avenues for COVID-19 therapies.

Keywords:
SARS CoV-2gRNA packagingnucleocapsidphase separation

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