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Retraction Note to: MicroRNA-322 Cluster Promotes Tau Phosphorylation via Targeting Brain-Derived Neurotrophic Factor
Jun Zhang1,2, Zanchao Liu3, Yuanyuan Pei1
1Department of Pathology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, People's Republic of China.
Abstract:
The Editors have retracted this article [1] following an investigation conducted by the journal. After publication concerns were raised regarding interpretation of the data presented in Fig. 4. The Editors requested additional data and clarification to confirm interpretation of data results. After further review, the Editors found that the additional data were not adequate to support the conclusion of the article and that P-values for the additional data were based on improper statistical analyses. With more appropriate statistical analysis, the reported effects for miR-322 and BDNF were not statistically significant. Dr. Chichu Xie agrees to this retraction. None of the other authors have responded to any correspondence from the publisher about this retraction.
Insights
This study on miR-322 and BDNF has been retracted due to issues with data interpretation and statistical analysis. The reported effects were found to be not statistically significant upon re-evaluation.
Area of Science:
- Biomedical Research
- Molecular Biology
- Neuroscience
Background:
- Concerns were raised regarding the interpretation of data in Figure 4.
- An investigation was initiated by the journal following these concerns.
Purpose of the Study:
- To re-evaluate the data and statistical analyses presented in the article.
- To confirm the validity of the reported effects of miR-322 and BDNF.
Main Methods:
- Journal editors requested additional data and clarification.
- Statistical re-analysis of the provided data was performed.
Main Results:
- Additional data were insufficient to support the article's conclusions.
- P-values were based on improper statistical analyses.
- Re-analysis revealed that reported effects for miR-322 and BDNF were not statistically significant.
Conclusions:
- The article has been retracted by the journal editors.
- The original findings regarding miR-322 and BDNF are not supported by the data.
- One author agrees with the retraction; others did not respond.
