Increased Levels of IL-34 in Acquired Immune-Mediated Neuropathies

Interleukin (IL)-34 is ligand for the colony-stimulating factor (CSF)-1 receptor. This cytokine has fundamental roles the pathogenesis of a number of autoimmune and neurologic disorders. However, its role in the pathogenesis of acute and chronic inflammatory demyelinating polyneuropathies (AIDP and CIDP) has not been assessed yet. We measured serum levels of IL-34 33 CIDP cases, 16 AIDP cases, and 33 control subjects using commercial ELISA kits. IL-34 levels were significantly higher in both AIDP (44.87 ± 4.38) and CIDP (44.87 ± 4.38) groups compared with healthy subjects (30.10 ± 1.05) (P = 0.046 and P = 0.01, respectively). Differences between female subgroups were insignificant. However, levels of this cytokine were significantly higher in male subjects with CIDP compared with male controls (P = 0.042). Thus, levels of this cytokine might be regarded as biomarkers for these kinds of autoimmune disorders. Future studies are needed to verify these results and find the molecular mechanism of participation of IL-34 in the pathogenesis of AIDP/CIDP.