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Serum myonectin is increased after laparoscopic sleeve gastrectomy
Lei Li1,2, Qianqian Wang3, Chengkun Qin2
1Emergency Center, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China.
Annals of Clinical Biochemistry
|June 27, 2020
Summary
Serum myonectin levels are lower in obese individuals and increase after laparoscopic sleeve gastrectomy. This finding highlights myonectin
Area of Science:
- Endocrinology and Metabolism
- Obesity Research
- Surgical Gastroenterology
Background:
- Myonectin, a novel myokine, influences fatty acid metabolism and is inversely associated with obesity.
- Reduced serum myonectin levels are observed in obese populations.
- Laparoscopic sleeve gastrectomy (LSG) is a common bariatric surgery for obesity.
Purpose of the Study:
- To investigate the changes in serum myonectin levels in obese patients following laparoscopic sleeve gastrectomy.
- To explore the correlation between serum myonectin and obesity-related parameters post-surgery.
Main Methods:
- A cohort of 42 obese patients undergoing LSG and 58 controls were studied.
- Serum myonectin, anthropometric data, lipid profiles, and HbA1c were measured pre- and 6 months post-LSG.
- Statistical analyses included regression to assess correlations.
Main Results:
- Obese patients exhibited significantly lower baseline serum myonectin compared to controls.
- Serum myonectin levels increased significantly six months after LSG.
- Serum myonectin showed inverse correlations with weight, BMI, waist circumference, and HbA1c, with BMI remaining significant after adjustment.
Conclusions:
- Serum myonectin levels are significantly associated with obesity.
- Laparoscopic sleeve gastrectomy leads to an increase in serum myonectin.
- Myonectin may play a role in the metabolic improvements observed after bariatric surgery.
