Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bi-allelic variants in CDK20 cause a severe ciliopathy with midline brain and facial anomalies.

American journal of human genetics·2026

Same author

Pathogenic variants in BORCS5 cause a spectrum of neurodevelopmental and neurodegenerative disorders with lysosomal dysfunction.

The Journal of clinical investigation·2026

Same author

Diagnostic yield and imaging: aetiology correlations in prenatal intracranial haemorrhage-a retrospective cohort study.

Archives of disease in childhood. Fetal and neonatal edition·2026

Same author

The fetal taenia-tela choroidea complex: a radiologic-pathologic correlation from normal anatomy to Dandy-Walker malformation.

Pediatric radiology·2026

Same author

Periventricular Nodular Heterotopia, Cerebellar Hypodysgenesis, and Mesial Temporal Malformation Detected on Fetal MRI: An Underrecognized Association.

AJNR. American journal of neuroradiology·2026

Same author

A 100-year simulation of the National Kidney Registry's voucher program.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2025

Search research articles

Related Experiment Video

Updated: Dec 17, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Central nervous system pathology in the amniotic rupture sequence.

Patrick Shannon

Clinical Neuropathology

|June 27, 2020

Summary

Amniotic rupture sequence (ARS) central nervous system (CNS) pathology is linked to craniofacial clefts. Specific brain anomalies like aqueductal stenosis and holoprosencephaly frequently occur with ARS.

Area of Science:

Neuropathology
Developmental Biology
Fetal Medicine

Background:

Amniotic rupture sequence (ARS) is a condition with diverse fetal malformations.
Understanding the central nervous system (CNS) involvement in ARS is crucial for diagnosis and management.

Purpose of the Study:

To delineate and review the CNS pathology associated with ARS.
To identify extraneural associations of ARS-related CNS malformations.

Main Methods:

A review of a 15-year fetal/neonatal autopsy series was conducted.
Cases of ARS were analyzed for CNS morphology and associated anomalies.

Main Results:

Fifteen cases of ARS with complete CNS dissection were identified.

More Related Videos

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Mouse Models of Periventricular Leukomalacia

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

Related Experiment Videos

Last Updated: Dec 17, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Mouse Models of Periventricular Leukomalacia

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

CNS pathology was strongly associated with craniofacial clefts, including acalvaria and encephalocele.

Non-random associations were observed between aqueductal stenosis (AS), holoprosencephaly, and ARS, with specific brain malformations noted in cases with encephalocele.

Conclusions:

CNS pathology in ARS is significantly linked to craniofacial abnormalities.
The co-occurrence of AS, holoprosencephaly, and ARS suggests specific developmental pathways are involved.
Potential etiologies include abnormal induction, vascular instability, and mechanical factors from craniofacial maldevelopment.