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Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography
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Fat grafting: Early hypoxia, oxidative stress, and inflammation developing prior to injection

Nathalie Kerfant1, Gaëlle Albacete2, Anthony Guernec2

  • 1Department of plastic surgery CHRU de Brest, Boulevard Tanguy Prigent, 29609 BREST cedex, France; ORPHY, EA 4324 : Laboratoire Optimisation des Régulations Physiologiques, Université de Bretagne Occidentale, 6 avenue Le Gorgeu, 29238 Brest cedex 3, France.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|June 28, 2020
PubMed
Abstract

No abstract available in PubMed .

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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