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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Renewal of Intestinal Stem Cells01:23

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Mucosal Barrier of the Stomach01:25

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The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
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Related Experiment Video

Updated: Dec 17, 2025

Investigating Intestinal Barrier Breakdown in Living Organoids
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LncRNA: A Potential Research Direction in Intestinal Barrier Function.

Zhi-Feng Jiang1, Lin Zhang2

  • 1Center of Emergency and Intensive Care Unit, Jinshan Hospital of Fudan University, Medical Research Center for Chemical Injury of Fudan University, No. 1508 Longhang Road, Shanghai, 201508, China.

Digestive Diseases and Sciences
|June 28, 2020
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are key players in various diseases and biological processes. This review explores their emerging role in maintaining intestinal barrier function and potential as a future research area.

Keywords:
BiogenesisInflammatory bowel diseaseIntestinal barrierIntestinal barrier dysfunctionLncRNAUlcerative colitis

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Area of Science:

  • Molecular Biology
  • Genetics
  • Gastroenterology

Background:

  • Long non-coding RNAs (lncRNAs) are RNA transcripts exceeding 200 nucleotides.
  • lncRNAs regulate critical biological processes, including cell differentiation, development, and apoptosis.
  • The intestinal barrier is a vital human protective layer, and its dysfunction is linked to diseases like inflammatory bowel disease.

Purpose of the Study:

  • To review the current understanding of lncRNA roles in intestinal barrier function.
  • To explore the potential of lncRNAs as a novel research avenue in the context of the intestinal barrier.

Main Methods:

  • Literature review of existing studies on lncRNAs and intestinal barrier.
  • Synthesis of current findings on lncRNA involvement in intestinal barrier integrity and disease.

Main Results:

  • lncRNAs have demonstrated associations with intestinal barrier function in preliminary research.
  • Evidence suggests lncRNAs participate in regulating intestinal barrier integrity.

Conclusions:

  • lncRNAs represent a promising area for future research concerning intestinal barrier health.
  • Further investigation into lncRNAs could yield new insights into gastrointestinal diseases.