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Unfolded protein response in cardiovascular disease
Khadeja-Tul Kubra1, Mohammad S Akhter1, Mohammad A Uddin1
1School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Cellular Signalling
|June 28, 2020
Summary
The unfolded protein response (UPR) protects cells but can impact cardiovascular health. Manipulating UPR
Area of Science:
- Cellular Biology
- Molecular Biology
- Cardiovascular Science
Background:
- The unfolded protein response (UPR) is a critical cellular stress pathway.
- UPR activation is linked to various physiological and pathological conditions, including cardiovascular diseases.
Purpose of the Study:
- To present the latest information on the role of UPR in cardiovascular function.
- To explore how UPR influences the improvement or deterioration of cardiovascular health.
Main Methods:
- Literature review of current research on UPR and cardiovascular disease.
- Analysis of the three main UPR signaling pathways: ATF6, PERK, and IRE1α.
Main Results:
- UPR activation has a dual role in cardiovascular health, potentially improving or worsening outcomes.
- Specific UPR branches (ATF6, PERK, IRE1α) differentially affect cardiovascular function.
Conclusions:
- Understanding the complex role of UPR in cardiovascular disease is crucial.
- Targeting specific UPR molecular branches may offer novel therapeutic strategies for cardiovascular diseases.
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