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Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

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Transmissible Cancers in an Evolutionary Perspective.

Antoine M Dujon¹, Robert A Gatenby², Georgina Bramwell¹

¹Deakin University, Geelong, School of Life and Environmental Sciences, Centre for Integrative Ecology, Waurn Ponds, Vic 3216, Australia.

|June 28, 2020

Summary

This summary is machine-generated.

Cancer can spread between individuals like a contagious disease, offering insights into tumor evolution and host interactions. This phenomenon, known as transmissible cancer, is a unique host-pathogen system with significant evolutionary implications.

Keywords:

Biological Sciences Cancer Evolutionary Biology Evolutionary Ecology

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Area of Science:

Evolutionary biology
Cancer research
Ecology

Background:

Transmissible cancers are rare clonal malignant cell lines that spread horizontally between hosts.
Only nine transmissible cancer lineages across eight species have been documented.
These cancers offer a unique model for studying tumor-host interactions and evolutionary dynamics.

Purpose of the Study:

To provide an overview of known transmissible cancers.
To discuss the conditions necessary for cancer transmission.
To review the evolutionary dynamics between transmissible cancers and their hosts.

Main Methods:

Literature review of documented transmissible cancer lineages.
Analysis of ecological and evolutionary factors influencing cancer transmission.
Synthesis of existing research on tumor-host interactions in transmissible cancers.

Main Results:

Identified nine transmissible cancer lineages in diverse host species.
Outlined key conditions facilitating horizontal cancer cell transmission.
Detailed the evolutionary dynamics observed in these host-pathogen systems.

Conclusions:

Transmissible cancers represent a unique host-pathogen system with significant ecological and evolutionary implications.
Studying these cancers provides novel insights into tumor evolution, metastasis, and host-pathogen interactions.
Further research into transmissible cancers can advance our understanding of cancer biology and evolution.