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Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
From pre-tumor to tumor: Decoding the endoscopic-pathologic spectrum of neoplastic lesions in autoimmune gastritis
Fengmei Zhong1, Yingchao Zhang2, Ziguang Liu1
1Department of Pathology, the Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong 528000, China.
Abstract:
Autoimmune gastritis (AIG) is a chronic atrophic gastritis predisposing to neuroendocrine tumors (NETs), dysplasia, and gastric cancer (GC). In a cohort of 1,551 patients with suspected AIG, we identified 46 with neoplastic lesions and 134 without such lesions and compared their clinicopathological and endoscopic features. NETs typically appeared as polypoid/submucosal tumors with dilated vessels or central depression; epithelial neoplasms showed variable morphologies, with irregular microvessels under narrow-band imaging (NBI). Extensive corpus atrophy and antral patchy redness were independent risk factors for AIG-associated neoplasia, whereas female sex was protective. These findings support a risk model integrating clinical, endoscopic, and pathological features for individualized surveillance.
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