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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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The oncogenic role of Jagged1/Notch signaling in cancer

Meng-Xi Xiu1, Yuan-Meng Liu1, Bo-Hai Kuang1

  • 1Medical School of Nanchang University, 603 Bayi Road, Nanchang, Jiangxi 330006, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 29, 2020
PubMed

Insights

Aberrant Notch signaling, driven by Jagged1 (JAG1), promotes cancer. Inhibiting JAG1 offers a promising therapeutic strategy for various cancers, potentially reducing toxicity associated with broader Notch pathway inhibitors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling Pathways

Background:

  • Aberrant activation of Notch signaling is a key driver in cancer development.
  • Jagged1 (JAG1), a Notch ligand, is frequently overexpressed in cancers and linked to poor prognosis.
  • JAG1/Notch signaling regulates critical oncogenic processes including proliferation, metastasis, drug resistance, and angiogenesis.

Purpose of the Study:

  • To review the oncogenic role of Jagged1 (JAG1)/Notch signaling in cancer.
  • To discuss the implications of JAG1 as a therapeutic target for cancer treatment.
  • To explore strategies for inhibiting JAG1/Notch signaling activity to overcome pan-Notch inhibitor toxicity.

Main Methods:

  • Literature review synthesizing current research on JAG1/Notch signaling in cancer.
  • Analysis of the oncogenic functions regulated by JAG1/Notch cascades.
  • Evaluation of therapeutic strategies targeting JAG1.

Main Results:

  • JAG1 overexpression is a significant factor in multiple cancer types, correlating with adverse clinical outcomes.
  • JAG1/Notch signaling pathways activate oncogenic factors essential for tumor progression and resistance.
  • Targeting JAG1 presents a more specific approach compared to pan-Notch inhibitors, potentially mitigating severe toxicities.

Conclusions:

  • JAG1/Notch signaling is a critical oncogenic pathway in cancer development and progression.
  • JAG1 represents a valuable therapeutic target for developing novel anti-cancer strategies.
  • Inhibiting JAG1 offers a promising avenue for cancer therapy with potentially reduced side effects.
Keywords:
CancerJAG1NotchOncogenicTherapy

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