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Related Concept Videos

Ultrasonography01:17

Ultrasonography

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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
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Imaging Studies II: Ultrasonography01:24

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IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
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Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
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Ultrasound I: Abdominal Ultrasonography01:20

Ultrasound I: Abdominal Ultrasonography

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Introduction:
Abdominal ultrasonography, commonly known as abdominal ultrasound, is a vital, non-invasive medical imaging technique widely used in healthcare.
Procedure:
This diagnostic tool allows the clinician to visually inspect internal structures within the abdomen, including vital organs such as the liver, gallbladder, pancreas, kidneys, and spleen.
The abdominal ultrasound process begins with applying a special gel to the patient's skin over the abdomen. This gel enhances the...
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Related Experiment Video

Updated: Dec 17, 2025

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
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Molecular Ultrasound Imaging.

Jasmin Baier1, Anne Rix1, Fabian Kiessling2

  • 1Institute for Experimental Molecular Imaging Organization University Clinics, RWTH Aachen University, Forckenbeckstrasse 55, 52074 Aachen, Germany.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|June 29, 2020
PubMed
Summary

Molecular contrast-enhanced ultrasound (CEUS) uses targeted microbubbles to detect cancer markers like VEGFR2, showing promise in early clinical trials for safety and tumor detection. This technology also aids in monitoring tumor growth and evaluating therapy response.

Keywords:
Active targetingBR55CEUSImagingIntegrinMicrobubbleUltrasound imagingVEGFR2

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Area of Science:

  • Medical Imaging
  • Nanotechnology
  • Oncology

Background:

  • Contrast-enhanced ultrasound (CEUS) is crucial for diagnostics.
  • Microbubbles are common ultrasound contrast agents, with novel nano-materials under investigation.
  • Molecular CEUS utilizes targeted agents for specific disease marker detection.

Purpose of the Study:

  • To review applications of molecular ultrasound for monitoring tumor growth and neovascularization.
  • To evaluate therapy responses using molecular CEUS.
  • To present findings from early clinical trials of molecular CEUS.

Main Methods:

  • Modification of ultrasound contrast agents to target molecular markers (e.g., VEGFR2, αvβ3 integrin).
  • Application of molecular CEUS for longitudinal monitoring of receptor expression.
  • Conducting clinical trials with VEGFR2-targeted microbubbles.

Main Results:

  • Molecular CEUS can longitudinally monitor receptor expression during tumor growth.
  • The technique effectively detects neovascularization and evaluates therapy responses.
  • Initial clinical trials demonstrated patient safety and successful tumor detection in prostate, breast, and ovarian cancers.

Conclusions:

  • Molecular CEUS shows significant potential for preclinical and clinical diagnostics.
  • VEGFR2-targeted microbubbles are safe and effective for tumor detection.
  • Future applications include ultrasound theranostics for enhanced drug delivery.