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Updated: May 19, 2026
10:39
Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
Published on: March 4, 2015
Molecular Ultrasound Imaging
Anne Rix1, Jasmin Baier1, Fabian Kiessling2
1Institute for Experimental Molecular Imaging, University Hospital, RWTH Aachen University, Northrhein-Westphalia, Germany.
Summary
Molecular contrast-enhanced ultrasound (CEUS) uses targeted microbubbles to detect cancer markers like VEGFR2. Early clinical trials show promising safety and tumor detection in prostate, breast, and ovarian cancers.
Area of Science:
- Medical imaging
- Nanotechnology
- Oncology
Background:
- Contrast-enhanced ultrasound (CEUS) is a key diagnostic tool.
- Microbubbles are common ultrasound contrast agents.
- Novel nanomaterials are being explored for CEUS applications.
Purpose of the Study:
- To explore molecular CEUS for targeted disease detection.
- To investigate ultrasound contrast agents targeting cancer markers.
- To evaluate the potential of molecular ultrasound in oncology.
Main Methods:
- Modification of ultrasound contrast agents with ligands for molecular targeting.
- Utilizing agents targeting neoangiogenesis markers like VEGFR2 and αvβ3-Integrin.
- Application in preclinical and clinical settings for tumor imaging.
Main Results:
- Molecular CEUS enables longitudinal monitoring of receptor expression during tumor growth.
- It effectively detects neovascularization and evaluates therapy responses.
- First clinical trials with VEGFR2-targeted microbubbles show safety and tumor detection in prostate, breast, and ovarian cancers.
Conclusions:
- Molecular CEUS is a safe and effective method for tumor detection.
- Targeted ultrasound contrast agents show potential for improved cancer diagnostics.
- Future applications include ultrasound theranostics for enhanced drug delivery.
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