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Iodothyronines in human bile.

P Langer1, R Moravec, B Ohrádka

  • 1Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

Endocrinologia Experimentalis
|March 1, 1988
PubMed
Summary
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Bile excretion of thyroid hormones in humans is minimal. This study found that biliary excretion of thyroxine (T4) and its metabolites is less significant for overall body balance compared to rats.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolism

Background:

  • Thyroid hormone metabolism and excretion pathways are crucial for maintaining homeostasis.
  • Biliary excretion is a known route for eliminating various substances from the body.
  • Previous studies suggested significant biliary excretion of iodothyronines in rats.

Purpose of the Study:

  • To quantify the biliary excretion of thyroid hormones in humans.
  • To compare the significance of biliary excretion of iodothyronines in humans versus rats.

Main Methods:

  • Collection of bile from 7 post-cholecystectomy patients with T-tube drainage over 24 hours.
  • Quantification of total thyroxine (T4), triiodothyronines (T3, rT3), and diiodothyronines (3,3'-T2, 3,5-T2, 3',5'-T2) using radioimmunoassay.

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Main Results:

  • The total amount of T4 excreted in bile was equivalent to its concentration in approximately 100 ml of plasma.
  • Excretion of triiodothyronines (T3, rT3) corresponded to levels in 1000-1500 ml of plasma.
  • Diiodothyronine excretion represented levels found in 10-15 liters of plasma, indicating very low concentrations.

Conclusions:

  • Biliary excretion of iodothyronines in humans is of considerably less importance for their total body balance than in rats.
  • The findings suggest alternative or more dominant pathways for thyroid hormone elimination in humans.