PERIODONTAL DISEASE IN DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE.

Area of Science:

• Periodontology
• Nephrology
• Immunology

Background:

• Periodontal disease is a prevalent chronic condition with systemic health implications.
• It is associated with chronic systemic diseases like diabetes and cardiovascular disease.
• Chronic inflammation and bacterial mediators are implicated in disease exacerbation.

Purpose of the Study:

• To investigate the association between periodontal disease and chronic kidney disease (CKD).
• To explore the role of inflammatory cytokines in this potential link.
• To compare periodontal status and cytokine levels between CKD stages.

Main Methods:

• Cross-sectional study of 80 subjects.
• Two groups: CKD stages III-IV and CKD stage V (hemodialysis).
• Assessed periodontal status and serum levels of interleukin-6, interleukin-17A, and tumor necrosis factor-α.

Main Results:

• No significant differences in periodontal status between the groups.
• Significantly higher interleukin-6 levels observed in the hemodialysis group.
• Elevated interleukin-6 levels were associated with poorer periodontal status.

Conclusions:

• Interleukin-6 may play a role in the relationship between periodontal disease and advanced chronic kidney disease.
• Hemodialysis patients exhibit higher inflammatory markers potentially linked to oral health.
• Further research is needed to elucidate the inflammatory pathways involved.