Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dose-effect analysis of 6-APB ("Benzofury") on fear memory, motor behavior, and reward.

Psychopharmacology·2026

Same author

Publisher Correction: Overactive bladder phenotype induced by chronic activation of hypothalamic neuroendocrine stress pathways in rats with no extrinsic behavioral stress applied.

Scientific reports·2026

Same author

Overactive bladder phenotype induced by chronic activation of hypothalamic neuroendocrine stress pathways in rats with no extrinsic behavioral stress applied.

Scientific reports·2025

Same author

A meta-analytic analysis of the acute effects of MDMA on empathy and emotion recognition in humans.

Scientific reports·2025

Same author

Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance calcium-activated potassium channels.

The Journal of physiology·2025

Same author

Impact of surgical bladder catheter implantation on voiding function in mice.

American journal of physiology. Regulatory, integrative and comparative physiology·2025

Search research articles

Related Experiment Video

Updated: Dec 17, 2025

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

Quantifying the Acoustic Startle Response in Mice Using Standard Digital Video.

Madeline M Pantoni¹, Gerald M Herrera^2,3, Kaitlin R Van Alstyne¹

¹Molecular Cognition Laboratory, Department of Psychology, University of California, San Diego, La Jolla, CA, United States.

Frontiers in Behavioral Neuroscience

|June 30, 2020

Summary

This study demonstrates using the VideoFreeze system to measure the acoustic startle response in mice. This approach validates automated startle response assessment, offering a cost-effective alternative for researchers.

Keywords:

fear conditioning methods neuropsychiatric disorders phenotyping prepulse inhibition rodent models startle video

More Related Videos

A Low Cost Setup for Behavioral Audiometry in Rodents

A Low Cost Setup for Behavioral Audiometry in Rodents

Published on: October 16, 2012

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

Related Experiment Videos

Last Updated: Dec 17, 2025

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

A Low Cost Setup for Behavioral Audiometry in Rodents

A Low Cost Setup for Behavioral Audiometry in Rodents

Published on: October 16, 2012

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

Area of Science:

Neuroscience
Behavioral Neuroscience

Background:

The acoustic startle response is a fundamental reflex used in translational research.
Rodent startle response studies typically require specialized stabilimeter chambers.
Existing systems are limited to measuring only the startle response.

Purpose of the Study:

To validate the VideoFreeze system for assessing the acoustic startle response in mice.
To demonstrate the utility of standard video technology for automated startle response measurement.
To provide researchers with an integrated solution for fear conditioning and startle response assessment.

Main Methods:

Utilized the VideoFreeze system, commonly used for fear conditioning, to measure acoustic startle response in freely moving mice.
Quantified startle response amplitude and prepulse inhibition of startle.
Employed standard video technology for automated data acquisition.

Main Results:

Successfully validated the VideoFreeze system for accurate quantification of acoustic startle response.
Demonstrated the system's capability to measure both startle response amplitude and prepulse inhibition.
This marks the first use of standard video in automated rodent acoustic startle response assessment.

Conclusions:

The VideoFreeze system can be effectively used to assess the acoustic startle response in mice.
This offers a valuable, integrated approach for researchers studying fear conditioning and sensorimotor gating.
Researchers can leverage existing VideoFreeze equipment for startle response analysis, avoiding additional costs.