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The Role of Long Non-Coding RNAs in Thyroid Cancer
Xuejiao Peng1, Kun Zhang2, Li Ma1
1Department of Thyroid Surgery, Second Affiliated Hospital of Jilin University, Changchun, China.
Abstract:
Thyroid cancer, the most common endocrine malignancy, has become the most commonly diagnosed malignant solid tumor. Moreover, some cases have poor prognosis, and the survival period is only 3-5 months. Long noncoding RNAs (lncRNAs) are a group of functional RNA molecules more than 200 nucleotides in length that lack the ability to encode protein but participate in all aspects of gene regulation. Functionally, many lncRNAs play essential roles in epigenetic regulation at transcriptional and post-transcriptional levels via various molecular mechanisms. Recent studies have discovered important roles for lncRNAs during the complex process of carcinogenesis in thyroid cancer. In this review, we focus on lncRNAs dysregulated in thyroid cancer and summarize recently reported associations between lncRNAs and thyroid cancer in order to demonstrate the significant value of lncRNAs in diagnosis and treatment.
Insights
Thyroid cancer is the most common endocrine malignancy. Long noncoding RNAs (lncRNAs) are increasingly recognized for their crucial roles in thyroid cancer development, offering potential for new diagnostic and therapeutic strategies.
Area of Science:
- Endocrinology
- Molecular Biology
- Oncology
Background:
- Thyroid cancer is the most common endocrine malignancy and a leading cause of cancer diagnosis.
- Some thyroid cancer cases present with poor prognosis, with survival rates as low as 3-5 months.
- Long noncoding RNAs (lncRNAs) are key regulators of gene expression involved in various biological processes.
Purpose of the Study:
- To review the dysregulation of lncRNAs in thyroid cancer.
- To summarize recent findings on the association between lncRNAs and thyroid cancer.
- To highlight the potential of lncRNAs in thyroid cancer diagnosis and treatment.
Main Methods:
- Literature review of recent studies on lncRNAs and thyroid cancer.
- Analysis of lncRNA functions in gene regulation and epigenetic mechanisms.
- Focus on lncRNAs implicated in thyroid carcinogenesis.
Main Results:
- lncRNAs play significant roles in the complex process of thyroid cancer development.
- Dysregulated lncRNAs are observed in thyroid cancer tissues.
- lncRNAs are involved in epigenetic regulation at transcriptional and post-transcriptional levels.
Conclusions:
- lncRNAs are critical players in thyroid cancer pathogenesis.
- lncRNAs show promise as diagnostic biomarkers for thyroid cancer.
- lncRNAs represent potential therapeutic targets for thyroid cancer treatment.
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