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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
Published on: September 11, 2020
The Role of MicroRNA in Contrast-Induced Nephropathy: A Scoping Review and Meta-Analysis
Mangiring P L Toruan1,2, Raymond Pranata3, Budi Yuli Setianto4
1Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia.
Objective:
Early diagnosis of contrast-induced nephropathy (CIN) remains crucial for successful treatment; unfortunately, the widely used serum creatinine is elevated only in the late stage of CIN. The circulating microRNAs (miRNAs) are stable biomarker that might be useful. The aim of this scoping review and meta-analysis is to assess the role of miRNAs in CIN.
Methods:
We performed a systematic literature search on topics that assess the role of miRNAs in CIN from several electronic databases.
Results:
There were 6 preclinical studies and 2 of them validated their findings in human. Only miR-30a, miR-30c, miR-30e, and miR-188 have been validated in human models. Meta-analysis showed that increase in miR-30a expression was associated with higher incidence of CIN (OR 4.48 [1.52, 13.26], p = 0.007; I 2: 94%, p < 0.001). An increase in miR-30e expression was associated with higher incidence of CIN (OR 2.34 [1.70, 3.20], p < 0.001; I 2: 0%, p = 0.76). There is an indication that miR-188 is associated with contrast-induced apoptosis and might potentially be a drug target in the future.
Conclusion:
This study highlighted the importance of certain miRNAs in CIN pathophysiology. Future researches should explore on the prognostic and therapeutic implication of miRNA in CIN.
Insights
Certain microRNAs (miRNAs) show promise as early biomarkers for contrast-induced nephropathy (CIN). Increased miR-30a and miR-30e levels are linked to higher CIN incidence, suggesting their diagnostic and therapeutic potential.
Area of Science:
- Biochemistry
- Molecular Biology
- Nephrology
Background:
- Contrast-induced nephropathy (CIN) diagnosis is challenging due to delayed serum creatinine elevation.
- Circulating microRNAs (miRNAs) offer potential as stable and early biomarkers for CIN.
- Current diagnostic methods for CIN lack sensitivity in early stages.
Purpose of the Study:
- To conduct a scoping review and meta-analysis to evaluate the role of miRNAs in CIN.
- To identify specific miRNAs that can serve as early diagnostic markers for CIN.
- To assess the prognostic and therapeutic implications of miRNAs in CIN pathophysiology.
Main Methods:
- Systematic literature search across multiple electronic databases for studies on miRNAs and CIN.
- Inclusion of preclinical and human studies investigating miRNA biomarkers for CIN.
- Meta-analysis to quantify the association between specific miRNA expression and CIN incidence.
Main Results:
- Six preclinical studies and two human validation studies were identified.
- miR-30a, miR-30c, miR-30e, and miR-188 were validated in human models.
- Increased miR-30a (OR 4.48) and miR-30e (OR 2.34) expression correlated with higher CIN incidence.
- miR-188 shows potential as a drug target for contrast-induced apoptosis.
Conclusions:
- Specific miRNAs play a significant role in CIN pathophysiology.
- miR-30a and miR-30e are promising early biomarkers for CIN.
- Further research is needed to explore the prognostic and therapeutic applications of miRNAs in CIN.
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