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Relationship between the night shift work and thyroid disorders: A systematic review and meta-analysis
Luca Coppeta1, Luca Di Giampaolo2, Stefano Rizza3
1Italian study group on the metabolic and immunological effects of night shift workDepartment of Occupational Medicine, University of Rome Tor Vergata, Rome, Italy.
Endocrine Regulations
|June 30, 2020
Summary
Night shift work is linked to higher thyroid stimulating hormone (TSH) levels. This disruption may stem from altered circadian rhythms and sleep patterns, impacting worker health.
Area of Science:
- Endocrinology
- Occupational Health
- Public Health
Background:
- Night shift work is associated with various health issues, including hormonal irregularities.
- Thyroid disorders represent a significant health concern potentially linked to shift work.
Purpose of the Study:
- To systematically review and meta-analyze the association between night shift work and thyroid disorders.
- To investigate the impact of night shift work on thyroid function markers.
Main Methods:
- A comprehensive literature search was conducted across eight databases (e.g., PubMed, Google Scholar).
- Systematic review and meta-analysis were performed following the PRISMA statement guidelines.
- Included studies involved participants working night shifts versus day shifts.
Main Results:
- Six studies with 4074 participants were included in the systematic review.
- Meta-analysis of four studies (1864 night shift workers, 2017 day shift workers) revealed significantly higher thyroid stimulating hormone (TSH) levels in night shift workers.
- This finding indicates a potential thyroid dysfunction link to night shift work.
Conclusions:
- Elevated TSH in night shift workers is likely due to circadian rhythm and sleep/wake cycle disruption.
- Disrupted biological rhythms may also contribute to eating disorders.
- Further attention is warranted regarding the health implications of night shift work patterns.
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