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Prognostic Value of Inflammation Parameters in Patients With Non-ST Elevation Acute Coronary Syndromes

Kenan Guclu1, Mustafa Celik2

  • 1Department of Biochemistry, Kirsehir Training and Research Hospital, Kirsehir, Turkey.

Angiology
|June 30, 2020
PubMed

Insights

Total antioxidant status (TAS) effectively predicts long-term mortality in non-ST elevation acute coronary syndrome (NSTE-ACS) patients. Other inflammation markers like MHR, LMR, NLR, PLR, and oxidative stress indices showed no independent predictive value.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Medicine

Background:

  • Inflammation markers are linked to coronary artery disease severity and mortality.
  • Previous studies have not collectively assessed multiple inflammation parameters for prognostic value in NSTE-ACS.
  • Non-ST elevation acute coronary syndrome (NSTE-ACS) requires reliable predictors of long-term outcomes.

Purpose of the Study:

  • To compare the prognostic capabilities of various inflammation parameters in predicting long-term mortality among NSTE-ACS patients.
  • To identify specific biomarkers that can independently predict mortality in this patient cohort.

Main Methods:

  • A cohort of 170 consecutive NSTE-ACS patients was analyzed.
  • Measurements included Monocyte/HDL-C ratio (MHR), Lymphocyte/Monocyte ratio (LMR), Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), lipid ratios (TC/HDL-C, TG/HDL-C), Total Antioxidant Status (TAS), Total Oxidant Status (TOS), oxidative stress index, and Ischemia-Modified Albumin (IMA).

Main Results:

  • Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) emerged as significant independent predictors of mortality.
  • A TAS cutoff value of 1.17 demonstrated 70.0% sensitivity and 77.39% specificity for predicting mortality.
  • MHR, LMR, NLR, PLR, lipid ratios, TOS, and IMA were not found to be independent predictors of mortality in NSTE-ACS.

Conclusions:

  • Total Antioxidant Status (TAS) is a valuable independent predictor of long-term mortality in patients with NSTE-ACS.
  • Several commonly assessed inflammation and oxidative stress markers lack independent prognostic value for mortality in this population.
  • TAS measurement offers a potential tool for risk stratification in NSTE-ACS management.

Keywords:
inflammationmortalitynon-ST acute coronary syndromeoxidative stresstotal antioxidant status

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