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'Bioluminescent' Reporter Phage for the Detection of Category A Bacterial Pathogens

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Published on: July 8, 2011

Rapid diagnostic tests for plague.

Sophie Jullien¹, Harsha A Dissanayake², Marty Chaplin³

¹Barcelona Institute for Global Health, University of Barcelona, Barcelona, Spain.

The Cochrane Database of Systematic Reviews

|June 30, 2020

Summary

This summary is machine-generated.

A rapid diagnostic test (RDT) for plague shows high sensitivity in detecting pneumonic and bubonic plague against culture. However, false positives necessitate confirmatory tests like PCR or culture for accurate diagnosis and treatment guidance.

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Rapid Molecular Detection and Differentiation of Influenza Viruses A and B

Rapid Molecular Detection and Differentiation of Influenza Viruses A and B

Published on: January 30, 2017

Area of Science:

Medical Microbiology
Diagnostic Accuracy Studies
Infectious Diseases Epidemiology

Background:

Plague is a severe, high-mortality disease where late diagnosis worsens outcomes and increases transmission risk.
A rapid diagnostic test (RDT) can facilitate prompt plague diagnosis, improving patient care and public health responses.

Purpose of the Study:

To evaluate the diagnostic accuracy of the F1 antigen-based rapid diagnostic test (F1RDT) for plague detection in suspected cases.

Main Methods:

Systematic review and meta-analysis of cross-sectional studies assessing F1RDT accuracy against reference standards (culture, PCR, serology).
Studies were assessed for quality and applicability using the QUADAS-2 tool.
Bivariate models were used for pooled sensitivity and specificity estimates, stratified by reference standard and plague form.

Main Results:

Seven studies included eight manuscripts, evaluating F1RDT performance in Africa.
F1RDT-IPM demonstrated pooled sensitivity of 100% against culture for all plague forms (very low certainty evidence).
Pooled specificity against culture was 70.3% for all forms, 71% for pneumonic plague, and 67% for bubonic plague (very low to low certainty evidence).

Conclusions:

The F1RDT exhibits high sensitivity for diagnosing pneumonic and bubonic plague, aiding early detection in remote areas.
Positive F1RDT results may require confirmation by culture or PCR due to potential false positives.
Culture remains essential for antibiotic resistance and strain identification, complementing F1RDT results.