Related Experiment Video
Updated: Dec 17, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Replication of left ventricular haemodynamics with a simple planar mitral valve model
Anna Daub1, Jochen Kriegseis1, Bettina Frohnapfel1
1Institute of Fluid Mechanics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Abstract:
Tools for the numerical prediction of haemodynamics in multi-disciplinary integrated heart simulations have to be based on computational models that can be solved with low computational effort and still provide physiological flow characteristics. In this context the mitral valve model is important since it strongly influences the flow kinematics, especially during the diastolic phase. In contrast to a 3D valve, a vastly simplified valve model in form of a simple diode is known to be unable to reproduce the characteristic vortex formation and unable to promote a proper ventricular washout. In the present study, an adaptation of the widely used simplest modelling approach for the mitral valve is employed and compared to a physiologically inspired 3D valve within the same ventricular geometry. The adapted approach shows enhanced vortex formation and an improved ventricular washout in comparison to the diode type model. It further shows a high potential in reproducing the main flow characteristics and related particle residence times generated by a 3D valve.
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The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...

