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[Comorbidity in gout and hyperuricemia: prevalence, causes, prospects of urate lowering therapy]

M S Eliseev1, A M Novikova1

  • 1V.A. Nasonova Scientific and Research Institute of Reumatology.

Terapevticheskii Arkhiv
|June 30, 2020
PubMed

Insights

Gout and asymptomatic hyperuricemia are linked to serious health issues like diabetes and heart disease. Lowering uric acid levels can improve joint health and slow the progression of these life-threatening conditions.

Area of Science:

  • Nephrology
  • Cardiology
  • Rheumatology

Background:

  • Gout and asymptomatic hyperuricemia are increasingly recognized for their association with comorbid conditions.
  • These conditions include diabetes mellitus, cardiovascular diseases, hypertension, and chronic kidney disease.

Purpose of the Study:

  • To explore the connection between gout, asymptomatic hyperuricemia, and comorbid conditions.
  • To highlight the impact of urate crystal deposition on disease prognosis and progression.

Main Methods:

  • Review of studies investigating the link between hyperuricemia and comorbidities.
  • Analysis of the role of urate levels in cardiovascular and renal disease progression.

Main Results:

  • Asymptomatic hyperuricemia, not just gout, can worsen cardiovascular disease prognosis.
  • Urate crystal deposition is implicated in the cause and progression of renal failure.

Conclusions:

  • Timely urate-lowering therapy is crucial.
  • Achieving target serum uric acid levels can mitigate joint damage and slow the progression of life-threatening comorbidities.

Keywords:
allopurinolcardiovascular diseasecomorbiditydiabetesfebuxostatgouthyperuricemiametabolic syndromeuric acid

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