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[The cough variant asthma].
M O Uryasjev1, I V Ponomareva1, M Bhar1
1Ryazan State Medical University.
Terapevticheskii Arkhiv
|June 30, 2020
Summary
Cough variant asthma (CVA) is a type of asthma presenting only as a chronic cough. This condition involves airway hyperresponsiveness and inflammation, similar to classic asthma.
Area of Science:
- Pulmonology
- Allergy and Immunology
Background:
- Cough variant asthma (CVA) was initially described as isolated chronic cough responsive to bronchodilators.
- This asthma phenotype presents with airway hyperresponsiveness and eosinophilic inflammation.
- Unlike typical asthma, CVA lacks wheezing or dyspnea.
Purpose of the Study:
- To define the characteristics of cough variant asthma.
- To differentiate CVA from other causes of chronic cough.
- To highlight CVA's classification as a variant of asthma.
Main Methods:
- Clinical description and symptom analysis.
- Assessment of airway hyperresponsiveness.
- Evaluation of airway inflammation and remodeling markers.
Main Results:
- CVA is characterized by chronic cough as the sole presenting symptom.
- Patients exhibit airway hyperresponsiveness and eosinophilic inflammation.
- Bronchodilator therapy is effective for the cough in CVA.
Conclusions:
- Cough variant asthma is a distinct phenotype of asthma.
- Shared features with classic asthma include eosinophilic inflammation and airway remodeling.
- CVA is clinically recognized as a variant of asthma due to these commonalities.
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