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[Endothelial dysfunction in patients with controlled and uncontrolled arterial hypertension]

V I Podzolkov1, T A Safronova1, D U Natkina1

  • 1Sechenov First Moscow State Medical University (Sechenov University).

Terapevticheskii Arkhiv
|June 30, 2020
PubMed

Insights

Asymmetric dimethylarginine (ADMA) levels were significantly higher in patients with uncontrolled arterial hypertension (AH) compared to those with controlled AH. Elevated ADMA also correlated with higher creatinine levels in uncontrolled AH patients.

Area of Science:

  • Cardiovascular Research
  • Nephrology
  • Biochemistry

Background:

  • Arterial hypertension (AH) is a major cardiovascular risk factor.
  • Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase.
  • ADMA plays a role in endothelial dysfunction associated with hypertension.

Purpose of the Study:

  • To compare ADMA levels in patients with uncontrolled arterial hypertension (UCAH) versus controlled arterial hypertension (CAH).
  • To investigate the relationship between ADMA and clinical parameters in hypertensive patients.

Main Methods:

  • Comparative analysis of ADMA plasma concentrations in 109 hypertensive patients.
  • Patients were divided into two groups: UCAH (n=73) and CAH (n=36).
  • Clinical, laboratory, and instrumental examinations were performed.

Main Results:

  • ADMA concentration was significantly higher in the UCAH group compared to the CAH group.
  • A significant positive correlation was observed between ADMA and creatinine levels in patients with UCAH (r=0.615, p<0.05).

Conclusions:

  • Elevated ADMA levels are associated with uncontrolled arterial hypertension.
  • ADMA may serve as a biomarker for endothelial dysfunction and kidney function impairment in hypertensive individuals.
Abstract

Keywords:
arterial hypertensionasymmetric dimethylarginineendothelial dysfunctionsocially significant diseasesuncontrolled arterial hypertension

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