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Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
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Chitosan biomaterials application in dentistry
Elaheh Fakhri1, Hosein Eslami2, Parham Maroufi3
1Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
International Journal of Biological Macromolecules
|June 30, 2020
Summary
Chitosan, a natural polymer, shows promise in dental applications due to its biocompatibility and antimicrobial properties. This review highlights its use in oral drug delivery, bone tissue engineering, and dentin-pulp regeneration.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Dental Materials
Background:
- Chitosan, a deacetylated derivative of chitin, is a natural biopolymer with notable properties.
- Key characteristics include biocompatibility, biodegradability, non-toxicity, muco-adhesion, and antimicrobial activity.
- Its unique cationic nature and chemical modifiability enhance its versatility.
Purpose of the Study:
- To review the significant role of chitosan in the development of bio-dental materials.
- To highlight current applications of chitosan in the oral environment.
- To discuss strategies for enhancing chitosan's properties through chemical modification.
Main Methods:
- Literature review focusing on interdisciplinary research concerning chitosan.
- Analysis of studies on chitosan's application in oral drug delivery systems.
- Examination of research on chitosan for bone tissue engineering and dentin-pulp regeneration.
Main Results:
- Chitosan and its derivatives are effectively utilized in oral drug delivery systems.
- Chitosan shows significant potential in bone tissue engineering for periodontitis treatment.
- Applications in dentin-pulp regeneration are also discussed, showcasing chitosan's versatility.
Conclusions:
- Chitosan is a valuable biomaterial for advanced dental applications.
- Chemical modifications can further optimize chitosan's mechanical and biological properties for specific uses.
- The review underscores the growing importance and profitability of chitosan in the dental industry.
