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Updated: Aug 4, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
[Gynecologic interventions in von Willebrand-Jürgens syndrome (2 case reports)]
J Schmid1, P Heiz, G F Riedler
1Frauenklinik Kantonsspitals Luzern.
Abstract:
Gynecological procedures were performed in two patients with von Willebrand-Jürgens Syndrome. Although both patients were known to have the disorder and appropriate measures were taken, severe bleeding complications occurred in both cases, in the one shortly postoperatively and in the other after discharge from hospital. Based on our experience and a review of the literature, we recommend the following therapeutic concept: preoperative increase of vWF to over 50% and normalization of bleeding time by administration of FFP and AHF, postoperative substitution with 2-3 units FFP and 1-2 units AHF daily through the 15th day postsurgery.
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