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Related Experiment Video

Updated: Dec 17, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

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Published on: August 28, 2015

Development, Optimization and Characterization of Eudraguard^®-based Microparticles for Colon Delivery.

Claudia Curcio¹, Antonio S Greco¹, Salvatore Rizzo¹

¹Department of Drug Sciences, Section of Pharmaceutical Technology, University of Catania, 95125 Catania, Italy.

Pharmaceuticals (Basel, Switzerland)

|July 1, 2020

Summary

This study developed pH-dependent microparticles using Eudraguard® Biotic and Eudraguard® Control for colon delivery of quercetin. The emulsion-solvent evaporation method yielded optimal systems with limited gastric release and good colonic release.

Keywords:

DSC FT-IR PXRD drug delivery enteric release food-grade acrylate polymers quercetin

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Area of Science:

Pharmaceutical Sciences
Materials Science
Nutraceuticals

Background:

Developing pH-dependent systems for colon delivery of natural active ingredients is crucial for nutraceutical products.
Eudraguard® resins (methacrylate copolymers) are food-grade polymers suitable for food supplements.
Eudraguard® Biotic (EUG-B) offers pH-dependent solubility, while Eudraguard® Control (EUG-C) provides prolonged release.

Purpose of the Study:

To optimize microparticle preparation techniques for Eudraguard® resins.
To evaluate the encapsulation and specific colonic release of quercetin (QUE) using EUG-B and EUG-C.
To assess the in vitro release profiles simulating gastrointestinal tract pH variations.

Main Methods:

Preparation of unloaded and quercetin-loaded Eudraguard® microparticles using various techniques.
Solid-state characterization including FT-IR spectroscopy, differential scanning calorimetry, and X-ray diffractometry.
In vitro drug release studies simulating physiological pH changes in the gastrointestinal tract.

Main Results:

The emulsion-solvent evaporation method, without an aqueous phase, produced the best microparticle systems.
Solid-state analysis confirmed uniform dispersion of quercetin in a non-crystalline state within the polymer matrix.
In vitro tests demonstrated limited quercetin release in simulated gastric conditions and significant release in simulated colonic conditions.

Conclusions:

Eudraguard® Biotic and Eudraguard® Control microparticles are effective for colon-specific delivery of quercetin.
The emulsion-solvent evaporation method is optimal for preparing these microparticle systems.
These findings support the potential of Eudraguard® resins in developing advanced nutraceutical delivery systems.