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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
10.0K
Oncolytic viruses for cancer immunotherapy
Otto Hemminki1,2,3, João Manuel Dos Santos4,5, Akseli Hemminki6,7,8
1Division of Urologic Oncology, Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, Ontario, Canada. Otto.hemminki@helsinki.fi.
Journal of Hematology & Oncology
|July 1, 2020
Summary
Oncolytic viruses, particularly adenoviruses, show promise in cancer immunotherapy. Combining them with other treatments enhances efficacy and safety for better patient outcomes.
Area of Science:
- Oncology
- Virology
- Immunotherapy
Background:
- Oncolytic viruses have a long history of suggested efficacy and safety in cancer treatment.
- Adenoviruses serve as a model for understanding oncolytic virus versatility and therapeutic potential.
Purpose of the Study:
- To review the use of oncolytic viruses, focusing on adenoviruses, in cancer immunotherapy.
- To explore strategies for enhancing the efficacy of oncolytic virus therapy.
Main Methods:
- Review of historical reports and contemporary clinical trials on oncolytic viruses.
- Discussion of strategies including transgene addition, combination with conventional therapies, and immune checkpoint inhibitors.
Main Results:
- Oncolytic viruses, including adenoviruses, demonstrate safety and tolerability.
- Combining oncolytic viruses with immunomodulatory transgenes, radiotherapy, chemotherapy, and checkpoint inhibitors shows potential for increased efficacy.
- Oncolytic viruses can enhance tumor immunogenicity and modulate the tumor microenvironment for T cell therapies.
Conclusions:
- Oncolytic viruses represent a promising wave in cancer immunotherapy.
- Further research and clinical trials are ongoing to optimize oncolytic virus therapies and combinations.
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