Related Experiment Video

Updated: Dec 17, 2025

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
08:15

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System

Published on: April 11, 2025

745

RIPK1: A rising star in inflammatory and neoplastic skin diseases

Liping Jin1, Panpan Liu1, Mingzhu Yin1

  • 1Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China.

Journal of Dermatological Science
|July 1, 2020
PubMed

Insights

Receptor-interacting serine threonine kinase 1 (RIPK1) is crucial in cell death and inflammation, and its inhibitors may treat skin diseases like psoriasis and melanoma. This review explores RIPK1

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Many skin diseases, including psoriasis, lupus erythematosus, and melanoma, lack effective treatments.
  • Receptor-interacting serine threonine kinase 1 (RIPK1) is a key regulator of cell death pathways, particularly necroptosis.
  • RIPK1 activation is linked to inflammation and tumor development, making it a potential therapeutic target.

Purpose of the Study:

  • To review the molecular mechanisms of RIPK1 activation in inflammatory processes.
  • To summarize the current understanding of RIPK1's role in the pathogenesis of various skin diseases.
  • To highlight the therapeutic potential of RIPK1 inhibitors for dermatological conditions.

Main Methods:

  • Literature review of studies on RIPK1 signaling pathways.
  • Analysis of research on RIPK1's involvement in inflammation and cell death.
  • Synthesis of data on RIPK1's contribution to skin disease development.

Main Results:

  • RIPK1 activation is a critical checkpoint in inflammatory signaling cascades.
  • Dysregulation of RIPK1 ubiquitination contributes to the development of inflammatory skin conditions.
  • RIPK1 inhibitors have shown promise in preclinical models of skin diseases.

Conclusions:

  • RIPK1 is a significant molecular player in skin inflammation and disease.
  • Targeting RIPK1 offers a potential therapeutic strategy for intractable skin diseases.
  • Further research into RIPK1 modulation is warranted for dermatological applications.
Keywords:
InflammationMelanomaPsoriasisRIPK1Skin diseaseSystemic lupus erythematosus

More Related Videos

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

11.2K
Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells09:15

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

Published on: October 20, 2022

2.6K

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
11.3K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.6K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.9K
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.0K