Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

568
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
568
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

239
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
239
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

4.5K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanics Post-TAVR for Trileaflet vs Bicuspid Aortic Valves: Insights from Computational Simulation.

JACC. Advances·2025
Same author

Metachronal rowing provides robust propulsive performance across four orders of magnitude variation in Reynolds number.

Journal of the Royal Society, Interface·2025
Same author

Effects of implantation height on the performance of a redo transcatheter aortic valve replacement using a balloon-expandable valve.

JTCVS open·2024
Same author

Hemodynamics of the VenusP Valve Systemâ„¢-an <i>in vitro</i> study.

Frontiers in medical technology·2024
Same author

Reduced Order Modeling for Real-Time Stent Deformation Simulations of Transcatheter Aortic Valve Prostheses.

Annals of biomedical engineering·2023
Same author

Biomechanics of Transcatheter Aortic Valve Replacement Complications and Computational Predictive Modeling.

Structural heart : the journal of the Heart Team·2023

Related Experiment Video

Updated: Dec 17, 2025

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging
07:13

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

Published on: December 22, 2023

1.8K

Diastolic Vortex Alterations With Reducing Left Ventricular Volume: An In Vitro Study.

Milad Samaee1, Nicholas H Nelsen1, Manikantam G Gaddam1

  • 1School of Mechanical and Aerospace Engineering, Oklahoma State University, 201 General Academic Building, Stillwater, OK 74078.

Journal of Biomechanical Engineering
|July 1, 2020
PubMed
Summary

Reduced left ventricular (LV) volume, seen in conditions like hypertrophic cardiomyopathy, alters diastolic vortex ring dynamics. Lowering end-diastolic volume (EDV) increases peak circulation and decay rates, impacting LV filling.

Keywords:
diastolic vortexend diastolic volumehypertrophic cardiomyopathyintraventricular flowleft heart simulator

More Related Videos

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

8.2K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.4K

Related Experiment Videos

Last Updated: Dec 17, 2025

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging
07:13

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

Published on: December 22, 2023

1.8K
Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

8.2K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.4K

Area of Science:

  • Cardiovascular Physiology
  • Fluid Dynamics in Biology

Background:

  • Diastolic vortex ring dynamics are crucial for left ventricular (LV) filling.
  • Little is known about how reduced LV internal volume, common in LV diastolic dysfunction (LVDD) and hypertrophic cardiomyopathy (HCM) with LV hypertrophy (LVH), affects these dynamics.
  • Reduced LV volume increases confinement, potentially altering vortex ring properties.

Purpose of the Study:

  • To investigate the impact of reduced end-diastolic volume (EDV) and LV geometry on diastolic vortex ring properties.
  • To test the hypothesis that peak circulation and circulation decay rate are altered by decreasing EDV due to confinement.
  • To compare these effects in normal LV and HCM models.

Main Methods:

  • Utilized time-resolved particle image velocimetry (TR-PIV) on a left heart simulator.
  • Employed physical models simulating normal LV and HCM geometries.
  • Tested multiple EDVs under identical prescribed inflow profiles.

Main Results:

  • Vortex ring formation and pinch-off were largely unaffected by geometry and EDV changes, occurring before the E-wave in all conditions.
  • Peak circulation of the vortex core increased with decreasing EDV and was lowest in the HCM model.
  • Normalized circulation decay rate increased with decreasing EDV; a modified dimensionless time parameter normalized circulation across EDVs in the normal LV model.

Conclusions:

  • LV shape and internal volume significantly influence diastolic vortex ring dynamics.
  • Confinement due to reduced EDV alters vortex circulation and decay.
  • Findings are relevant for understanding diastolic dysfunction and congenital heart diseases.