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Cyclosporin in dermatology: A practical compendium.
Tazein Amber1, Saadia Tabassum2
1Fellowship Resident Dermatology, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan.
Dermatologic Therapy
|July 1, 2020
Summary
Cyclosporine A (CYA), an immunosuppressant, is effective for various skin conditions beyond psoriasis. While it has risks like kidney issues, its benefits in dermatology often outweigh those of other treatments.
Area of Science:
- Immunology
- Dermatology
- Pharmacology
Background:
- Cyclosporine A (CYA) is a calcineurin inhibitor with T-cell suppressive properties.
- Initially used for transplant rejection and graft-versus-host disease, CYA gained dermatological approval for psoriasis in 1997.
- It is also used off-label for atopic dermatitis, urticaria, lichen planus, and other skin disorders.
Purpose of the Study:
- To summarize the use of CYA in dermatological diseases.
- To review CYA's dosage, safety, monitoring, pharmacology, and drug interactions.
- To provide an evidence-based overview for clinicians.
Main Methods:
- A comprehensive literature search was conducted using Medline-PubMed, Google Scholar, and Uptodate.
- Evidence-based and peer-reviewed articles were analyzed.
- Information on CYA's application in skin diseases was synthesized.
Main Results:
- CYA is approved for psoriasis and used off-label for numerous other dermatoses.
- Common side effects include nephrotoxicity and hypertension, but overall safety is good in dermatological use.
- CYA demonstrates early therapeutic response and less myelosuppression compared to other immunosuppressants.
Conclusions:
- CYA is a valuable immunosuppressive agent in dermatology, offering significant benefits for various skin diseases.
- Treatment decisions should be individualized, weighing risks against benefits.
- CYA is often preferred due to its efficacy and favorable safety profile in dermatological applications.
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