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Plasma immunoreactive-trypsin(ogen) levels during development.

J J Levine1, J N Udall, K J Bloch

  • 1Department of Pediatric Gastroenterology, Schneider Children's Hospital, State University of New York at Stony Brook, New Hyde Park 11042.

Journal of Pediatric Gastroenterology and Nutrition
|May 1, 1988
PubMed
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Infant plasma cationic immunoreactive-trypsinogen levels are significantly higher than in adults. In infants, this trypsin was found bound to alpha 1-antitrypsin, unlike in adults.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Pediatric Medicine

Background:

  • Previous studies indicated higher intestinal uptake of intact trypsin in suckling animals compared to weaned animals.
  • Trypsin plays a crucial role in protein digestion and various physiological processes.

Purpose of the Study:

  • To investigate plasma levels of cationic immunoreactive-trypsinogen in humans across different age groups.
  • To determine the binding status of cationic immunoreactive-trypsinogen to alpha 1-antitrypsin in infants versus adults.

Main Methods:

  • Measurement of plasma cationic immunoreactive-trypsinogen concentrations.
  • Analysis of human subjects ranging from 3 days to 43 years of age.
  • Assessing the binding of cationic immunoreactive-trypsinogen to alpha 1-antitrypsin.

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Main Results:

  • Plasma cationic immunoreactive-trypsinogen concentrations were significantly elevated in 3-day-old infants compared to all other age groups.
  • In adult samples, no cationic immunoreactive-trypsin was found bound to alpha 1-antitrypsin.
  • A notable 28% of cationic immunoreactive-trypsin in infant samples was bound to alpha 1-antitrypsin.

Conclusions:

  • Human infants exhibit significantly higher plasma levels of cationic immunoreactive-trypsinogen.
  • The binding of cationic immunoreactive-trypsinogen to alpha 1-antitrypsin is age-dependent, occurring primarily in infants.
  • These findings suggest developmental differences in trypsin regulation and its interaction with inhibitors in early life.