Corticotropin-releasing factor: central nervous system effects on baroreflex control of heart rate

The effects of intracerebroventricular injections of corticotropin-releasing factor on baroreflex control of heart rate were examined in conscious, unrestrained rats. Baroreflex control of heart rate was tested by generating stimulus-response curves relating arterial pressure to pulse interval over a wide range of arterial pressures. Administration of corticotropin-releasing factor produced dose-related alterations of pressure-dependent curve parameters, e.g., range, gain and pressure at midrange. These results suggest that corticotropin-releasing factor alters transmission in neural pathways that process baroreceptor information.