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Toxic reactions and side effects of glucocorticoids in man
American Journal of Hospital Pharmacy
|May 1, 1977
Abstract:
The toxic reactions and side effects of glucocorticoids in humans are discussed. The effects reviewed include metabolic (muscle and skin, carbohydrates and lipids), cardiovascular, cellular, immunologic, skeletal and growth, gastrointestinal, nervous system, ocular, and hypothalmic-pituitary-adrenal.
Insights
Glucocorticoids can cause toxic reactions and side effects in humans, affecting multiple body systems. This review details adverse effects on metabolic, cardiovascular, immunologic, skeletal, and nervous systems, among others.
Area of Science:
- Pharmacology
- Endocrinology
- Toxicology
Background:
- Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties.
- Understanding their toxic reactions and side effects is crucial for patient safety.
Purpose of the Study:
- To comprehensively review the toxic reactions and side effects of glucocorticoids in humans.
- To categorize adverse effects across various physiological systems.
Main Methods:
- Literature review of studies on glucocorticoid toxicity.
- Systematic categorization of reported side effects.
Main Results:
- Glucocorticoid side effects impact metabolic functions (carbohydrates, lipids, muscle, skin).
- Adverse effects observed in cardiovascular, cellular, immunologic, skeletal, and growth systems.
- Impacts on gastrointestinal, nervous, ocular, and hypothalmic-pituitary-adrenal axes are significant.
Conclusions:
- Glucocorticoid therapy is associated with a broad spectrum of toxicities.
- Clinicians must carefully weigh benefits against risks, monitoring patients for these adverse effects.