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Updated: Dec 16, 2025
08:55
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
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Three Cases of Diffuse, Intense Stomach Uptake on DOTATATE PET
Martin S Auerbach1, Joseph R Pisegna2, Stephen Kim3
1From the Department of Nuclear Medicine and Department of Molecular and Medical Pharmacology.
Clinical Nuclear Medicine
|July 1, 2020
Summary
Diffuse and intense stomach uptake on DOTATATE PET scans can be a benign finding. This may be related to proton-pump inhibitor use, chronic gastritis, or gastrinoma, not always neuroendocrine tumors.
Area of Science:
- Nuclear medicine
- Gastroenterology
- Oncology
Background:
- DOTATATE Positron Emission Tomography (PET) scans are used for diagnosing neuroendocrine tumors.
- Incidental findings of tracer uptake in the stomach are becoming more common.
- Understanding the causes of stomach uptake is crucial for accurate diagnosis.
Observation:
- Three patients with suspected or known neuroendocrine tumors presented with diffuse and intense stomach uptake on DOTATATE PET.
- These patients underwent esophagogastroduodenoscopy and/or endoscopic ultrasound for further investigation.
Findings:
- The stomach uptake was attributed to three distinct causes: proton-pump inhibitor (PPI) use, chronic gastritis, and gastrinoma.
- This suggests that intense stomach DOTATATE uptake is not always indicative of malignancy.
Implications:
- Clinicians should consider benign conditions like PPI use and chronic gastritis when interpreting diffuse stomach uptake on DOTATATE PET.
- Differentiating between benign and malignant causes of stomach uptake is essential for appropriate patient management and avoiding unnecessary interventions.
- Further research may clarify the specific mechanisms and prevalence of these benign findings.
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