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Related Concept Videos

Enzymes02:34

Enzymes

91.6K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
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Introduction to Enzymes01:22

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The use of enzymes by humans dates to 7000 BCE. Humans first used enzymes to ferment sugars and produce alcohol without knowing that this was an enzyme-catalyzed reaction. Wilhelm Kuhne coined the term 'enzyme' in 1877 from the Greek words ‘en’ meaning ‘in’ or ‘within’ and ‘zyme’ meaning ‘yeast.’
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that...
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Enzyme Kinetics01:19

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Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
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Introduction to Enzyme Kinetics01:19

Introduction to Enzyme Kinetics

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Enzyme kinetics studies the rates of biochemical reactions. Scientists monitor the reaction rates for a particular enzymatic reaction at various substrate concentrations. Additional trials with inhibitors or other molecules that affect the reaction rate may also be performed.
The experimenter can then plot the initial reaction rate or velocity (Vo) of a given trial against the substrate concentration ([S]) to obtain a graph of the reaction properties. For many enzymatic reactions involving a...
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Enzyme Inhibition01:30

Enzyme Inhibition

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Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
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Introduction to Mechanisms of Enzyme Catalysis01:13

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For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
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Related Experiment Video

Updated: Dec 16, 2025

Modeling an Enzyme Active Site using Molecular Visualization Freeware
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Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

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Virtual laboratory lessons in enzymology.

Víctor Quesada1,2

  • 1Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, Oviedo, Spain.

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology
|July 1, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a novel online tool for simulating chemical reaction kinetics, aiding remote biochemistry education. The platform allows students to virtually explore enzymatic mechanisms and practice data analysis, enhancing learning during the COVID-19 pandemic.

Keywords:
computers in research and teachingenzymes and catalysislaboratory exercises

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Area of Science:

  • Biochemistry
  • Chemical Kinetics
  • Educational Technology

Background:

  • The COVID-19 pandemic necessitated remote learning, posing challenges for practical laboratory courses in universities.
  • Traditional laboratory experiments, crucial for understanding chemical kinetics and enzymatic mechanisms, are difficult to replicate in a virtual setting.

Purpose of the Study:

  • To present an online tool designed to simulate chemical reaction kinetics and enzymatic mechanisms for remote education.
  • To provide educators with a customizable platform for virtual laboratory exercises.
  • To facilitate student learning of data acquisition and processing in biochemistry.

Main Methods:

  • Development of an online simulation tool for chemical reaction kinetics.
  • Implementation of customizable features allowing professors to hide reaction mechanisms.
  • Utilizing the tool for virtual experiments focused on uncovering enzymatic parameters.

Main Results:

  • The online tool successfully simulates enzymatic mechanisms and reaction kinetics over time.
  • The customizable interface enables students to design virtual experiments to deduce reaction pathways.
  • Students can practice acquiring and processing data within a simulated laboratory environment.

Conclusions:

  • The developed online tool offers a viable solution for teaching chemical kinetics and enzymatic mechanisms remotely.
  • While not replacing all practical skills, the simulation enhances understanding of experimental design and data analysis.
  • This educational technology supports adaptive learning strategies in biochemistry during disruptions to in-person instruction.