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Updated: Dec 16, 2025
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
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Coronary Stent Thrombosis- Predictors and Prevention
Helen Ullrich1, Thomas Münzel, Tommaso Gori
1Cardiology Center, Cardiology I, Universitiy Medical Center, Johannes Gutenberg University Mainz,German Center of Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung,DZHK), Rhine-Main.
Deutsches Arzteblatt International
|July 2, 2020
Summary
Stent thrombosis (ST) is a serious complication after stent implantation. Prematurely stopping dual antiplatelet therapy (DAPT), cancer, and diabetes are key risks, while intracoronary imaging may reduce ST incidence.
Area of Science:
- Cardiology
- Interventional Cardiology
- Biomedical Engineering
Background:
- Stent thrombosis (ST) is a critical complication following stent implantation, carrying a significant mortality risk.
- Understanding ST mechanisms is crucial for all physicians involved in stent procedures.
- This review focuses on ST risk factors and novel treatment strategies.
Purpose of the Study:
- To present the identified risk factors for stent thrombosis (ST).
- To discuss innovative therapeutic approaches for managing ST.
- To provide a comprehensive overview of current knowledge on ST.
Main Methods:
- A selective literature search was conducted using PubMed.
- Current international guidelines and expert recommendations were incorporated.
- The review synthesizes data on ST risk factors and prevention strategies.
Main Results:
- Technical advancements and dual antiplatelet therapy (DAPT) have reduced ST frequency.
- Independent risk factors for ST include premature DAPT cessation (HR 26.8), malignancy (OR 17.45), and diabetes mellitus (OR 3.14).
- Intracoronary imaging in acute coronary syndrome patients reduced ST rates (0.6% vs. 1.2%) compared to angiography, enabling targeted interventions.
Conclusions:
- ST pathophysiology is multifactorial, posing research challenges.
- Prospective trials are necessary to validate the efficacy of systematic intracoronary imaging in reducing ST.
- Early detection and intervention using imaging can potentially prevent ST.
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