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Related Experiment Videos

Gastric bleeding in pseudoxanthoma elasticum.

L Kundrotas1, J Novak, J Kremzier

  • 1Department of Medicine, School of Medicine, SUNYAB, Buffalo.

The American Journal of Gastroenterology
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

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Pseudoxanthoma elasticum can cause gastrointestinal bleeding due to degenerative changes in gastric arterioles. This study documents these vascular changes over 26 years, revealing abnormal collagen fibers.

Area of Science:

  • Vascular Medicine
  • Gastroenterology
  • Dermatology

Background:

  • Pseudoxanthoma elasticum (PXE) is a rare genetic disorder characterized by calcification and degeneration of elastic fibers in various tissues.
  • Gastrointestinal bleeding is a known, though less common, complication of PXE.

Observation:

  • This report details a 26-year observation of a patient with PXE experiencing recurrent gastrointestinal bleeding.
  • Gastric arteriolar degeneration was documented, including internal elastic lamellar degeneration and dystrophic calcification.

Findings:

  • Ultrastructural analysis revealed an abnormal collagen fiber in addition to the typical degenerative changes.
  • These vascular alterations in the gastric submucosa are proposed as the direct cause of bleeding.

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Implications:

  • Understanding these vascular changes is crucial for managing gastrointestinal bleeding in PXE patients.
  • Further research into the role of abnormal collagen in PXE-related vascular fragility is warranted.