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Hypofractionated stereotactic radiosurgery for large-sized skull base meningiomas
Hyuk-Jin Oh1, Young Hyun Cho2,3, Jeong Hoon Kim4
1Department of Neurosurgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Journal of Neuro-Oncology
|July 2, 2020
Summary
Hypofractionated stereotactic radiosurgery (SRS) shows promise for large skull base meningiomas. This treatment achieved high tumor control rates and improved neurological function in patients with these complex tumors.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Stereotactic radiosurgery (SRS) is effective for intracranial meningiomas.
- Concerns exist regarding SRS for large skull base meningiomas due to critical structure proximity.
Purpose of the Study:
- To evaluate hypofractionated SRS for large skull base meningiomas.
- To assess tumor control and neurological outcomes in these patients.
Main Methods:
- 31 patients with large skull base meningiomas (>10 cm³)
- Treated with CyberKnife hypofractionated SRS (median 5 fractions, 27.8 Gy)
- Tumors located in middle/posterior skull base, including cavernous sinus, petroclival, and tentorial edge.
Main Results:
- 90.3% tumor control at median 57-month follow-up.
- 54.8% partial response (volume decrease >20%), 35.5% stable disease.
- 95.2% of patients with cranial neuropathy experienced improvement.
Conclusions:
- Hypofractionated SRS is a promising option for large skull base meningiomas.
- Offers effective tumor control and improved neurological outcomes.
- A reasonable therapeutic choice for select patients.
