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Published on: January 25, 2019
Benzofuran derivatives with nerve growth factor-potentiating activity from Phellinus ribis
Mei-Yue Dong1, Yan Zhang2, Hai-Qiang Jiang1
1School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, China.
Abstract:
Three new benzofuran derivatives, namely ribisin E (1) ribisin F (2) along with ribisin G (3) were isolated from the MeOH extract of the fruiting bodies of Phellinus ribis. Their structures were elucidated based on the NMR analysis. Furthermore, the absolute configuration of ribisin E (1) and ribisin G (3) were deduced by the CD calculations, and the absolute configuration of ribisin F (2) was determined by comparing its CD spectrum and specific rotation with the data of known analogues. All compounds (1-3) exhibited the activity of promoting neurite outgrowth in nerve growth factor (NGF)-ediated PC 12 cell at concentrations ranging from 1 to 30 μM.
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