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COVID-19 trials in Italy: A call for simplicity, top standards and global pooling

Aldo P Maggioni1, Felicita Andreotti2, Cristina Gervasoni3

  • 1ANMCO Research Center, Florence, Italy.

International Journal of Cardiology
|July 2, 2020
PubMed

Insights

The novel coronavirus disease (COVID-19) is a new global threat. Few clinical studies offer reliable data for effective treatment strategies, despite numerous research efforts.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • The novel coronavirus disease (COVID-19) emerged recently, causing a global pandemic with millions of infections and hundreds of thousands of deaths.
  • The rapid spread necessitates urgent development of effective treatments.

Purpose of the Study:

  • To evaluate the quality of clinical study designs for COVID-19 treatments.
  • To identify reliable evidence for clinical practice.

Main Methods:

  • Systematic review of clinical trials registered on ClinTrials.gov.
  • Assessment of study design validity.

Main Results:

  • Over 2,000 research projects are investigating COVID-19 treatments.
  • A significant number of studies lack sufficient validity to inform clinical practice.

Conclusions:

  • There is a critical need for high-quality research designs in COVID-19 treatment studies.
  • More reliable evidence is required to guide clinical decision-making during the pandemic.

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